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SLE And Back Pain Osteomyelitis can cause back pain, yet back pain is also caused from SLE, or Systemic lupus Erythematosus. Osteomyelitis causes back pain, since the disease merges a bacterial infection that spreads to the soft tissues and bones. Infections, open trauma, staphylococcus aureus, and hemolytic streptoc... Similar Editorial : Effective Back Pain Exercises by Lesley Lyon. | Source : Common Childhood Illness