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Cause Of Colon Cancer

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Colon cancer also known as colorectal cancer is cancer cells that are present in the long tube known as the large intestine and rectum. Some tumors found in this area are called polyps are not cancerous; however, tumors that are malignant are cancer. The polyps can be removed without the worry of spreading the disease, as they are not cancerous. Cancer of the colon or rectum on the other hand, can spread to other areas of the body and tissue. This occurs when cancer cells break away from the tumor and travel to other areas of the body, which is called metastasis, and can spread to the liver or the lungs. After metastasis occurs, the prognosis for a full recovery is dim.



The causes of Colon Cancer

As with practically all cancers, the exact causes are not known, however, risk factors that are present may help lead scientists to the answer. The risk factors for developing colon cancer include the following.

Individuals that eat a diet high in fat are at a higher risk of developing colon cancer. Those that eat a balanced diet and include such things as whole grains, fruits, and vegetables decrease their chances of developing colon cancer.

Colon polyps

Physicians believe that untreated polyps develop into colon cancer. In the majority of cases, these polyps are benign; however, over years without being removed the cells can change due to chromosome damage, which can become cancerous.

Ulcerative colitis

Ulcerative colitis can be a cause of colon cancer. This disorder brings on inflammation to the inner lining of the colon. In the majority of individuals with ulcerative colitis their chances of colon cancer begins to increase after 8 to 10 years of living with the disorder. Research shows colon cancer and individuals with ulcerative colitis include after 10 years 2.5% had colon cancer, after 30 years the rate rose to 7.6%, and after 50 years, it had risen to 10.8%.

Heredity

Past history of relatives with colon cancer increases the risk of this type of cancer. However, 80 percent of all patients do not have a family history of the disease.

Symptoms of Colon Cancer

Many people do not realize they have colon cancer due to the fact that the symptoms may not be present for many years after the development of the cancer cells. The symptoms can differ according to the location of the cancer or the tumor. The right colon is very large and in most cases, the symptoms are not apparent except for the possibility of becoming anemic due to iron deficiency due to the cancer. The left colon on the other hand is smaller and can cause partial or complete obstruction of the bowel bringing on constipation, diarrhea, cramps, bloating, and abdominal pain.

The main symptoms that are present with colon cancer include weakness, fatigue, change in bowel movements, shortness of breath, diarrhea, constipation, weight loss, cramps, bloating, abdominal pain, irritable bowel syndrome, peptic ulcer disease, Crohn's disease, ulcerative colitis, and diverticulosis.
Cause Of Colon Cancer
New research may link one of the species of bacteria that live in our digestive system to the development of colon cancer symptoms. Home to many species, some “good” and others “bad”, our digestive system provides these microbes a place to live, and in return they help with digestion and training the body's immune system. In susceptible people, this otherwise harmless organism causes DNA changes that can be a precursor to cancer.

The organism, known to scientists as enterococcus faecalis, (or E. faecalis for short) lives quietly in the digestive system of most of us, and it's true that not everyone develops colon cancer. For reasons scientists have yet to understand, in some people the organism produces an oxygen molecule known as superoxide that cause changes in DNA and prompt some of the gene action tied to cancer.

The research, conducted by the Department of Veterans Affairs Medical Center in Oklahoma City, looked at how colon cells reacted in the lab to the bacteria in the “fermentation” state. All in all, 42 genes linked to key processes in body cells were altered by the presence of E. faecalis.

"We found that superoxide led to strong signaling in immune cells called macrophages — it also altered the way some cells in the gut grew and divided and even increased the productivity of genes which are associated with cancer." says professor Mark Huycke, the lead researcher.

Experts in the UK also agree that bacteria may be likely culprits in cancers of the colon. Dr. Barry Campbell of the University of Liverpool agrees that E. faecalis could be involved, but he also believes that there are other bacteria in the bowel that play a part in the cell changes that eventually bring on tumors. He insists, "There is not going to be only one culprit. Our own team is interested in a particular type of E. coli with this in mind. There are also many other factors which are involved, such as genetics and environment."

And while the experts figure out what may be the root of the problem, there are things that you can do, right now, to reduce your risk. Living a healthy lifestyle where you eat right, exercise, don't smoke or drink to excess are important first steps. Keeping your weight under control will not only reduce your colon cancer risk, it will have you looking better and feeling better too.

You'll also want to learn all you can about colon cancer if you have a close family member like a parent or sibling with this disease. If you are at increased risk, your doctor will likely advise you to have colon screening tests before the usual age of 50. Don't put these off, and report promptly any change in your bowel habits to your doctor. Waiting in fear does you no good… and may rob you of your chance to fight your disease.

You'll also want to limit your exposure to toxins and radiation. While it takes a lot of radiation to get to a level that might cause cancer, you want to have tests you need but try to avoid exposure to unnecessary radiation.

Each year colon cancer claims nearly 50,000 lives, with over 100,000 patients newly diagnosed with colon cancer symptoms. Treatments include surgery, chemotherapy, radiation, immunotherapy and vaccine therapy. Clinical trials are also ongoing and yielding promising new leads all the time.
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Both Andrew Smith & Kirsten Whittaker are contributors for EditorialToday. The above articles have been edited for relevancy and timeliness. All write-ups, reviews, tips and guides published by EditorialToday.com and its partners or affiliates are for informational purposes only. They should not be used for any legal or any other type of advice. We do not endorse any author, contributor, writer or article posted by our team.

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