Antihypertensive; renin angiotensin system antagonist.
How the Drug Works
Eplerenone lowers blood pressure by blocking aldosterone from binding to mineralocorticoid receptors.
Uses
For the treatment of high blood pressure alone or in combination with other antihypertensive agents.
Precautions
Use with caution in the following situations
Pregnancy: There are no adequate and well-controlled studies in pregnant women. Use only if clearly needed and the potential benefits outweigh the possible risks to the fetus.
Breastfeeding: It is not known if eplerenone is excreted in breast milk. Consult your doctor before you begin breastfeeding.
Children: Safety and effectiveness have not been established.
Lab Tests: Lab tests may be required to monitor treatment. Tests include serum potassium level monitoring.
Drug Interactions
Tell your doctor or pharmacist if you are taking or planning to take any overthe-counter or prescription medications or dietary supplements with this drug. Drug doses may need to be modified or a different drug prescribed. The following drugs and drugs classes interact with this drug:
Potassium supplements or potassium-sparing diuretics (eg, amiloride, triamterene)
Side Effects
Every drug is capable of producing side effects. Many patients experience no, or minor, side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility. Possible side effects include:
Urinary and Reproductive Tract: Albumin in the urine; abnormal vaginal bleeding; breast enlargement or pain.
