You may start to feel better within 1 to 3 weeks of taking antidepressant medicine. But it can take as many as 6 to 8 weeks to see more improvement. If you have questions or concerns about your medicines, or if you do not notice any improvement by 3 weeks, talk to your doctor.

Your doctor may prescribe an atypical antipsychotic, such as aripiprazole (Abilify), if your depression does not improve with antidepressants alone.

Medications affect your brain chemistry in different ways, so you may try several different medications or combinations of medications to find treatment that works for your depression. Most people find a drug that works within a few tries, but for some people, depression can be more difficult to treat. In some cases, a combination of antidepressants may be necessary. Sometimes an antidepressant combined with a different type of medication-such as an antiseizure, mood stabilizer, or antianxiety drug-is effective.

When taking antidepressant medication, it is important that you take the medication as prescribed. It may take several weeks before you notice the medication working. Side effects may improve after your body adjusts to the medication.

Taking your medicine for at least 6 months after you feel better can help keep you from getting depressed again. If this is not the first time you have been depressed, your doctor may want you to take these medicines even longer.

If you decide to quit taking antidepressants, it is important that you gradually reduce the dose over a period of several weeks. Quitting antidepressants abruptly can cause withdrawal symptoms. It is important to discuss quitting (or changing) medications with your health professional.