Complete Information on Canavan Disease

By: Juliet Cohen

The Canavan disease is the aspartic acid metabolism the confusion which inherits. It for degeneration (dispersing) brain white question description. This kind of disease the group gene chaotic is called leukodystrophies one by one. The Canavan disease is inherited the autosomal recessive fashion. The Canavan disease creates by a slight defect ASPA gene. This enzyme division by centralized brain member N acetazolamide aspartate. The aspartoacylase activity which reduces is prevented N the acetazolamide aspartate normal breakdown, and lacks the breakdown by some method interference nerve fiber myelin sheath growth in the brain.

The myelin sheath is surrounds the nerve cell and the motion takes the insulator, considered the nerve impulse the high efficiency the transmission fatty cover. The Canavan disease symptom, appears in the early initial period and rapidly progresses, perhaps included previously the movement skillful intelligence flaw, the loss which gained, fed, the unusual muscle difficultly anxious, was unusual big with, badly is controlled the head. Perhaps the paralysis, blindness, or hearing loss and occurs. The child typically peaceful and is aloof. The Canavan disease possibly identifies that screen by the simple pre-natal blood test for to lack the enzyme.

Canavan disease causes progressive brain atrophy. Treatment is symptomatic and supportive. There is no cure or effective treatment for Canavan disease but several approaches are currently being explored. The first is gene therapy whereby functional aspartoacylase genes are introduced into an affected child's brain to increase the levels of aspartoacylase. The second is the introduction of functional neuronal stem cells into an affected child's brain to increase the number of neurons that make aspartoacylase. Physical therapy minimizes contractures and maximizes motor abilities and seating posture. Seizures are treated with anti-epileptic drugs.

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