What is the most important information I should know about tramadol?



Seizures have been reported as a rare side effect of treatment with tramadol. The risk of seizures may be increased in patients who take more than the prescribed dose, have a history of seizures or epilepsy, have head trauma, have a metabolic disorder, have a central nervous system infection, are experiencing alcohol or drug withdrawal, or are taking certain medications. Talk to your doctor about factors that may increase the risk of seizures during treatment.

Do not drink alcohol while taking tramadol. Alcohol may cause a dangerous decrease in breathing and/or liver problems when used during treatment with tramadol.

Use caution when driving, operating machinery, or performing other hazardous activities. Tramadol may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Do not take more of this medication than is prescribed for you. If the pain is not being controlled, talk to your doctor. Taking more than the prescribed amount of this medication could result in seizures or decreased breathing.

What is tramadol?

Tramadol is a pain reliever. Tramadol affects chemicals and receptors in the body that are associated with pain.

Tramadol is used to relieve moderate to moderately severe pain.

Tramadol may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking tramadol?

Seizures have been reported as a rare side effect of treatment with tramadol. The risk of seizures may be increased in patients who have any of the conditions or are taking any of the medications listed below: Do not take tramadol without first talking to your doctor if you

•have a history of seizures or epilepsy;

•have a head injury;

•have a metabolic disorder;

•have a central nervous system infection;

•are experiencing alcohol or drug withdrawal;

•are taking a tricyclic antidepressant such as amitriptyline (Elavil), nortriptyline (Pamelor), doxepin (Sinequan), imipramine (Tofranil), clomipramine (Anafranil), and others;

•are taking a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate);

•are taking a psychiatric medication such as chlorpromazine (Thorazine), fluphenazine (Prolixin), haloperidol (Haldol), loxapine (Loxitane), mesoridazine (Serentil), perphenazine (Trilafon), thioridazine (Mellaril), thiothixene (Navane), and others;

•are taking a selective serotonin reuptake inhibitor (SSRI) such as fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or citalopram (Celexa);

•are taking a narcotic pain reliever such as codeine, fentanyl (Duragesic), hydromorphone (Dilaudid), meperidine (Demerol), hydrocodone (Vicodin, Lorcet, Lortab, others), morphine (MS Contin, MSIR, RMS, Roxanol, others), oxycodone (Roxicodone, Percocet, Percodan, others), propoxyphene (Darvon, Darvocet, others), and others;

•are taking promethazine (Phenergan) or prochlorperazine (Compazine);

•are taking sibutramine (Meridia);

•are taking bupropion (Wellbutrin, Zyban); or

•Are taking cyclobenzaprine (Flexeril).

Before taking tramadol, tell your doctor if you have

•kidney disease;

•liver disease; or

•a history of alcohol or drug dependence.

Do not take more of this medication than is prescribed for you. If the pain is not being controlled, talk to your doctor. Taking more than the prescribed amount of this medication could result in seizures or decreased breathing.

Store tramadol at room temperature away from moisture and heat.

What happens if I miss a dose?

Since tramadol is taken on an as-needed basis, missing a dose is usually not a problem. Take the dose as soon as you remember, and do not take another dose for the amount of time prescribed by your doctor. Do not take a double dose of this medication.

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